2026

·  Gullapalli T, Willow J, Karkhah A, Munjal V, Nimmo A, Ceyhan K, Travis M, O’Brien A, Rocco M, Taunque A, Townsend K, Samaranch L. AAV2 Capsid Clearance and Neuronal Trafficking Dynamics in the Central Nervous System. Gene Therapy . 2026 Apr; - PMID: 42056501

·  Samaranch L, Neudorfer C, Rocco M, O’Brien A, Munjal V, McFarland N, Taunque A, Ceyhan K, Travis M, Dandamudi A, Karkhah A, Nimmo A, Bringas J, Akhter A, Keister A, Mattox L, Youngblood B, Richardson M, Forsayeth J, Lonser R, Bankiewicz KS. Single-pass surgical approach for multi-target AAV2-hAADC delivery in nonhuman primate brainstem. Molecular Therapy - Advances. 2026 Jan 12;34(1):201670 - PMID: 42137299

2025

·  Dimitrov T, Munjal V, O’Brien A, Rocco M, Karkhah A, Ceyhan K, Prevedello D, Samaranch L. AAV9-mediated transduction of memory circuits after convection-enhanced delivery into olfactory bulbs. Gene Therapy. 2025 Dec;32(6):657-663. - PMID: 40715486

2023

·  Ford MM, George BE, Van Laar VS, Holleran KM, Naidoo J, Hadaczek P, Vanderhooft LE, Peck EG, Dawes MH, Ohno K, Bringas B, McBride JL, Samaranch L, Forsayeth JR, Jones SR, Grant KA, Bankiewicz KS. GDNF gene therapy for alcohol use disorder in male nonhuman primates. Nature Medicine. 2023 Aug;29(8):2030-2040. - PMID: 37580533

2019

·  Samaranch L, Pérez-Cañamás A, Soto-Huelin B, Sudhakar V, Jurado-Arjona J, Hadaczek P, Ávila J, Bringas JR, Casas J, Chen H, He X, Schuchman EH, Cheng SH, Forsayeth J, Bankiewicz KS, Ledesma MD. AAV9-based gene therapy for Niemann-Pick disease type A. Science Translational Medicine. 2019 Aug 21; 11(506). - PMID: 31434754

·  Sudhakar V, Naidoo J, Samaranch L, Bringas J, Lonser R,  Fiandaca MS, Bankiewicz KS. 'Infuse as you go' convective delivery to enhance coverage of elongated brain targets. Journal of Neurosurgery. 2019 Jul; 12:1-8. - PMID: 31299656

·   Sudhakar V, Mahmoodi A, Bringas J, Naidoo J, Kells A, Samaranch L, Fiandaca MS, Bankiewicz KS. Development of a Novel Frameless Skull-Mounted Ball-Joint Guide Array for use in Stereotactic Neurosurgery. Journal of Neurosurgery. 2019 Feb; 15:1-10. - PMID: 30771782

·  Samaranch L, Ohno K, San Sebastian W, Bankiewicz KS. Cerebellomedullary cistern injection of viral vectors in non-human primates. Methods in Molecular Biology. 2019; 1937:313-324. - PMID: 30706407

Previous work at UCSF

2018

·  Ohno K, Samaranch L, Hadaczek P, Bringas JR, Allen P, Sudhakar V, Stockinger DE, Snieckus C, Campagna M, San Sebastian W, Naidoo J, Hwa GGC, Chen H, Forsayeth J, Bankiewicz KS. MR-based real-time flow and kinetics of AAV9 vector after delivery into cerebrospinal fluid of nonhuman primate. Molecular Therapy – Methods & Clinical Development. 2018 Dec 8;13:47-54.

·  Naidoo J, Stanek L, Ohno K, Trewman S,  Samaranch L, Hadaczek P, O'Riordan C, Sullivan J, San Sebastian W, Bringas JR,  Snieckus C, Mahmoodi AN, Mahmoodi AR, Forsayeth J, Bankiewicz KS and Shihabuddin LS. Extensive transduction and enhanced spread of a modified AAV2 capsid in the non-human primate central nervous system. Molecular Therapy. 2018 Oct 3;26(10):2418-2430

·  Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto P, San Sebastian W, Samaranch L, Bankiewicz KS, Tuszynski MH. MR-Guided delivery of AAV2-BDNF into the Entorhinal Cortex of Non-Human Primates. Gene Therapy. 2018 Apr;25(2):104-114

·  Yazdan-Shahmorad A, Tian N, Kharazia V, Samaranch L, Kells A, Bringas JP, He J, Bankiewicz K, Sabes PN Widespread Optogenetic Expression in Macaque Cortex Obtained with MR-Guided, Convection Enhanced Delivery (CED) of AAV vector to the Thalamus. Journal of Neuroscience Methods. 2018 Jan 1;293:347-358.

2017

·  Samaranch L, Blits B, San Sebastian W, Hadaczek P, Bringas JP, Sudhakar V, Macayan M, Pivirotto PJ, Forsayeth J, Petry H, Bankiewicz, KS. MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain. Gene Therapy. 2017 Apr;24(4):253-261

·  Ciesielska A, Samaranch L, San Sebastian W, Dickson D, Goldman S, Forsayeth J, Bankiewicz KS. Depletion of AADC activity in caudate nucleus and putamen of Parkinson's disease patients; Implications for ongoing AAV2-AADC gene therapy trial. PlosOne. 2017 Feb 6;12(2):e0169965

2016

·   Dreising K, Pedersen LS, Hadaczek P, Degn M, Kornum BR, San Sebastian W, Samaranch L, Bankiewicz KS. Validation of antibodies for neuroanatomical localization of the P2Y11 receptor in macaque brain. Journal of Chemical Neuroanatomy. 2016 Aug 8;78:25-33

·  Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Samaranch L, Forsayeth J, Cheng S, Bankiewicz KS, and Shihabuddin L. Widespread AAV1- and AAV2-mediated Transgene Expression in the Nonhuman Primate Brain: Implications for Huntington's Disease. Molecular Therapy - Methods & Clinical Development. 2016 Jun 29;3:16037

·  Green F, Samaranch L, Zhang S, Manning-Bog A, Meyer K, Forsayeth F, Bankiewicz KS. Axonal transport of AAV9 in nonhuman primate brain. Gene Therapy. 2016 Jun;23(6):520-6

·  Samaranch L, Bringas J, Pivirotto P, San Sebastian W, Forsayeth J, Bankiewicz KS. Cerebellomedullary cistern delivery for AAV-based Gene therapy: A technical note for non-human primates. Human Gene Therapy Methods. 2016 Feb;27(1):13-6

·  Samaranch L, Hadaczek P, Kells AP, Bringas J, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS. Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response. Gene Therapy. 2016 Apr;23(4):393-8

2014

·  San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto P, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS. Safety and tolerability of MRI-guided infusion of AAV2-hAADC into the mid-brain of Non-Human Primate. Molecular Therapy - Methods & Clinical Development. 2014 Oct;15:3

·  Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS. Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy. Frontiers in Neuroanatomy. 2014 Mar;8(9):1-8

·   Passini MA, Bu J, Richards AM, Treleaven CM, Sullivan JA, O’Riordan CR, Scaria A, Kells AP, Samaranch L, San Sebastian W, Federici T, Fiandaca MS, Boulis NM, Bankiewicz KS, Shihabuddin LS, Cheng SH. Translational fidelity of intrathecal delivery of scAAV9-SMN1 for spinal muscular atrophy. Human Gene Therapy.2014 Jul;25(7):619-30

·  Samaranch L, San Sebastian W, Kells A.P, Salegio E.A., Bringas J, Pivirotto P, DeArmond S, Forsayeth J, Bankiewicz K.S. AAV9-mediated expression of a non-self protein in non-human primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction. Molecular Therapy. 2014 Feb;22(2):329-37

2013

·  San Sebastian W, Samaranch L, Heller G, Kells A.P, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz K.S. Adeno-associated virus type 6 is retrogradely transported in the Non-Human Primate brain. Gene Therapy. 2013 Dec;20(12):1178-83

·  Samaranch L, Salegio EA, San Sebastian W, Kells AP, Bringas JR, Forsayeth J, Bankiewicz KS. Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the CSF of Non-Human primates. Human Gene Therapy.2013 May;24(5):526-32

·  Salegio EA, Samaranch L, Kells AP, Mittemeyer G, San Sebastian W, Zhou S, Beyer J, Forsayeth J, Bankiewicz KS. Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Therapy. 2013 Mar;20(3):348-52

2012

·  Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, San Sebastian W, Richardson RM, Rosenbluth KH, Fiandaca MS, Forsayeth J, Hannun YA and Bankiewicz KS. Safety study of AAV2-mediated human acid sphingomyelinase expression in the non-human primate brain. Human Gene Therapy. 2012 Aug;23(8):891-902.

·  Samaranch L, Salegio EA, Kells AP, San Sebastian W, Foust KD, Bringas JR, Lamarre C, Forsayeth JR, Kaspar BK, Bankiweicz KS. Adeno-associated virus serotype 9 transduction in the central nervous system of non-human primates. Human Gene Therapy. 2012 Apr:23(4):382-389.